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Current hepatitis B treatment guidelines and future research directions

Jonathan Skupsky,Ke-Qin Hu

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 145-157 doi: 10.1007/s11684-014-0335-1

Abstract: half a million people dying annually from HBV related disease.Significant advances have been made in HBV treatment in the past decade and several guidelines have beenAlthough these recommendations have been valuable to help optimize HBV treatment, there is discordancein treatment criteria and many patients infected with HBV may fall outside of these recommendations.the natural history of the disease and compares and contrasts the recommendations for initiation of treatment

Keywords： chronic hepatitis B     HBV treatment guidelines     APASL guidelines     EASL guidelines     AASLD guidelines    

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Impact of HBV replication in peripheral blood mononuclear cell on HBV intrauterine transmission

Xiaohong Shi, Xuefei Wang, Xixi Xu, Yongliang Feng, Shuzhen Li, Shuying Feng, Bo Wang, Suping Wang

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 548-553 doi: 10.1007/s11684-017-0597-5

Abstract: cell (PBMC) from HBsAg-positive mothers on HBV intrauterine transmission.Within 24 h after birth, HBV serological markers, serum HBV DNA, PBMC HBV relaxed circular DNA (rcDNAThe relationship between HBV replication in PBMC and HBV intrauterine transmission was examined throughMaternal PBMC HBV cccDNA was a risk factor of HBV intrauterine transmission (OR= 6.003, 95% CI: 1.249&plays a critical role in HBV intrauterine transmission.

Keywords： PBMC     HBV cccDNA     HBV rcDNA     HBV intrauterine transmission    

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Current recommendations of managing HBV infection in preconception or pregnancy

James S. Park,Calvin Pan

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 158-165 doi: 10.1007/s11684-014-0340-4

Abstract:

Hepatitis B remains a leading cause of cirrhosis, hepatocellular carcinoma and liver transplantation worldwide. Management of chronic hepatitis B during pregnancy is challenging. Transmission of hepatitis B to infants still occurs perinatally although immunoprophylaxis is widely available for infants born to mothers with chronic hepatitis B infection. The emerging data suggest that initiation of antiviral therapy in the beginning of the third trimester in highly viremic mothers can prevent immunoprophylaxis failure in their infants. The available drug safety data show that lamivudine, telbivudine and tenofovir are generally safe to be used during the pregnancy. In order to minimize the fetal exposure to the antiviral medication, antiviral therapy during the pregnancy should be limited to a selected group of patients with cirrhosis, high hepatitis B viral load, or prior history immunoprophylaxis failure. An elective Caesarean section may reduce the risk of perinatal transmission. For those females planning for pregnancy or in early stage of pregnancy, communication and follow-up among obstetrician, gastroenterologist, and primary care physician are important. In this article, we will review the features of hepatitis B infection before, during and after the pregnancy; the risk factors that increase mother-to-child transmission; safety data on antiviral drug use during pregnancy; and the potential role of Caesarean section in selected cases.

Keywords： antiviral therapy     Caesarean section     cirrhosis     hepatitis B     immunoprophylaxis     mother-to-child transmission     pregnancy     prevention    

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New perspective on the natural course of chronic HBV infection

Yong-Yuan Zhang,Ke-Qin Hu,Zhongping Duan

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 129-134 doi: 10.1007/s11684-014-0339-x

Abstract:

Chronic hepatitis B virus (HBV) infection is a significant threat to public health and an enormousMechanisms responsible for chronic HBV infection remain poorly understood.Natural course of chronic HBV infection is conventionally viewed as an uninterrupted process that iswith assumed host responses to HBV infection.and reinfection, and such cycles prolong the chronic HBV infection course.

Keywords： hepatitis B virus     chronic HBV infection     natural course     hepatitis B     seroconversion    

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A Resilience Approach for Diagnosing and Predicting HBV-Related Diseases based on Blood Tests Article

Gege Hou,Yunru Chen,Xiaojing Liu,Dong Zhang,Zhimin Geng,Shubin Si

Engineering 2024, Volume 32, Issue 1,   Pages 174-185 doi: 10.1016/j.eng.2023.06.013

Abstract:

Chronic hepatitis B virus (HBV) infection, which threatens global publicExaminations for liver diseases related to chronic HBV infection—including laboratory tests, ultrasoundsestablish an economical and effective diagnosis method in order to streamline the medical process for HBV-related

Keywords： HBV-related diseases     Functional resilience     Improve medical resource utilization     Critical states     Network    

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Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide

Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 502-508 doi: 10.1007/s11684-017-0590-z

Abstract:

Although the efficacy of nucleos(t)ide analogue (NA) has been confirmed for treatment of chronic hepatitisIn this review, the RNA virion-like particles of hepatitis B virus (HBV) are integrated into the lifecycle of HBV replication, and the potential significance of serum HBV RNA is systematically describedThe production of HBV RNA virion-like particles should not be blocked by NA; in this regard, serum HBVTherefore, the concept of virological response is redefined as persistent loss of serum HBV DNA and HBV

Keywords： chronic hepatitis B     serum HBV RNA     nucleos(t)ide analogs     virological response     para-functional cure    

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Eliminating mother-to-child transmission of HBV: progress and challenges in China

Wenzhan Jing, Jue Liu, Min Liu

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 21-29 doi: 10.1007/s11684-020-0744-2

Abstract: China has the world’s largest burden of hepatitis B virus (HBV) infection, but the country has made considerableStudies on the optimal antiviral treatment regimen for pregnant women with high HBV-DNA load have alsoHowever, China still faces challenges in eliminating MTCT of HBV.than that of the national level because of limited health resources and public health education for HBVIntegration of current services to prevent MTCT of HBV with other relevant health services can increase

Keywords： hepatitis B virus     mother-to-child transmission     progress     challenge    

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Review of recent guidelines for the management of severe sepsis and septic shock

Jin-Nong ZHANG MD, Bo PENG BA, Jamile WOODS MD, Wei PENG MD, PhD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 54-58 doi: 10.1007/s11684-010-0008-7

Abstract: Advancements in treatment and disease management led to a decline in in-hospital mortality from 27.8%In this article, we systemically review recent guidelines for the management of severe sepsis and septicshock published in 2008 by the International Surviving Sepsis Campaign Guidelines Committee.The 2008 Surviving Sepsis guidelines recommend protocolized resuscitation with goals to maintain central

Keywords： sepsis     septic shock     hemodynamics     guidelines    

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The imperative need to develop guidelines to manage human versus machine intelligence

Donald KENNEDY, Simon P. PHILBIN

Frontiers of Engineering Management 2018, Volume 5, Issue 2,   Pages 182-194 doi: 10.15302/J-FEM-2018085

Abstract: Machine intelligence is increasingly entering roles that were until recently dominated by human intelligence. As humans now depend upon machines to perform various tasks and operations, there appears to be a risk that humans are losing the necessary skills associated with producing competitively advantageous decisions. Therefore, this research explores the emerging area of human versus machine decision-making. An illustrative engineering case involving a joint machine and human decision-making system is presented to demonstrate how the outcome was not satisfactorily managed for all the parties involved. This is accompanied by a novel framework and research agenda to highlight areas of concern for engineering managers. We offer that the speed at which new human-machine interactions are being encountered by engineering managers suggests that an urgent need exists to develop a robust body of knowledge to provide sound guidance to situations where human and machine decisions conflict. Human-machine systems are becoming pervasive yet this research has revealed that current technological approaches are not adequate. The engineering insights and multi-criteria decision-making tool from this research significantly advance our understanding of this important area.

Keywords： human intelligence & machine intelligence     HI-MI     decision-making     artificial intelligence    

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Emergent limited perioperative transesophageal echocardiography: should new guidelines exist for limited

Yong G. Peng, Gregory M. Janelle

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 332-337 doi: 10.1007/s11684-012-0212-8

Abstract: We believe there is an urgent need to develop (1) practical guidelines for emergent perioperative TEEa requisite educational curriculum to teach the basic skills necessary to aid in the diagnosis and treatment

Keywords： transesophageal echocardiography     curriculum     competency training     hemodynamic instability    

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Guidelines for navigation-assisted spine surgery

Wei Tian, Bo Liu, Da He, Yajun Liu, Xiaoguang Han, Jingwei Zhao, Mingxing International Society for Computer Assisted Orthopaedic Surgery

Frontiers of Medicine 2020, Volume 14, Issue 4,   Pages 518-527 doi: 10.1007/s11684-020-0775-8

Abstract: However, no clinical guidelines have been published for this relatively new and fast-growing techniqueaccordance with the consensus of consultant specialists, literature reviews, and our local experience, these guidelines

Keywords： guidelines     spine surgery     computer-assisted navigation    

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Design guidelines for urea hydrolysers for ammonia demand of the SCR DENOX project in coal-fired power

Peng ZHENG, Xuan YAO, Wei ZHENG

Frontiers in Energy 2013, Volume 7, Issue 1,   Pages 127-132 doi: 10.1007/s11708-012-0225-7

Abstract: mature urea hydrolysis technology for the DENOX project in China; therefore, this paper proposes several guidelinesThis paper endeavors to propose suggestions and guidelines to develop domestically urea hydrolysers in

Keywords： urea     hydrolyser     ammonia     selective catalytic reduction (SCR)    

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dry-toilet collected matters from suburban areas of Ulaanbaatar, Mongolia, using biosolids quality guidelines

Xuan LIU,Zifu LI,Eric BOSC,Heinz-Peter MANG

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 5,   Pages 710-718 doi: 10.1007/s11783-013-0592-2

Abstract: Dry-toilet collected matter (DCM) from traditional dry-toilet pits are a potential health and ecological risk in suburban areas. In this study, the characteristics of metals in DCMs from suburban areas of Ulaanbaatar were surveyed. The results indicate that DCMs contain a high percentage of organic matter and nutrients, while heavy metals are at low levels, which shows good agricultural potential. The concentration ranges of Cr, Cu, Hg, Ni, Pb, and Zn were 11±5, 46±9, 0.08±0.05, 9±3, 17±9, and 338±86 mg·kg , respectively. The concentration of Cd was below 0.5 mg·kg , and a high positive relation was shown between chromium and nickel concentrations. The heavy metals in DCMs were safe for land application but Zn in DCMs was close to the effects range median (ERM), which is toxic in some cases, such as amphipod bioassays. Because it is mandatory to treat DCMs to reduce pathogens, in the case of heavy metal enrichment and agricultural reuse, composting or pyrolysis are better choices than incineration. Compared with global soil background values, the heavy metals in DCMs showed a low level of ecological risk, but a medium level when compared with Mongolian soil background values. The ecological risk of six heavy metals was in the descending order Hg>Cu>Zn>Pb>Ni>Cr and the contribution rate of Hg exceeded 60%.

Keywords： heavy metals     suburban areas     dry-toilet     risk assessment    

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Essential training steps to achieving competency in the basic intraoperative transesophageal echocardiography examination for Chinese anesthesiologists

Yong G. Peng,Haibo Song,E. Wang,Weipeng Wang,Jin Liu

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 123-128 doi: 10.1007/s11684-014-0366-7

Abstract:

Guidelines for the intraoperative transesophageal echocardiography (TEE) examination have definedTEE training pathways and practice guidelines have been well established in western countries and manymodality to help in intraoperative management and surgical decision making, publishing basic TEE training guidelines

Keywords： transesophageal echocardiography     guidelines     training     competency    

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Current advances in the elimination of hepatitis B in China by 2030

Shuye Zhang, Fusheng Wang, Zheng Zhang

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 490-501 doi: 10.1007/s11684-017-0598-4

Abstract:

With its 78 million chronic carriers, hepatitis B virus (HBV) infection is still one of the leadingOver the last two decades, China has made great progress on the prevention of HBV transmission throughAvailable anti-HBV therapy is efficacious in suppressing HBV replication; however, it fails to completelycure patients with chronic hepatitis B and even requires lifelong treatment.Novel biomarkers were identified to predict treatment outcomes, and new promising treatment strategies

Keywords： HBV     CHB     biomarker     functional cure     coinfection    

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Title Author Date Type Operation

Current hepatitis B treatment guidelines and future research directions

Jonathan Skupsky,Ke-Qin Hu

Journal Article

Impact of HBV replication in peripheral blood mononuclear cell on HBV intrauterine transmission

Xiaohong Shi, Xuefei Wang, Xixi Xu, Yongliang Feng, Shuzhen Li, Shuying Feng, Bo Wang, Suping Wang

Journal Article

Current recommendations of managing HBV infection in preconception or pregnancy

James S. Park,Calvin Pan

Journal Article

New perspective on the natural course of chronic HBV infection

Yong-Yuan Zhang,Ke-Qin Hu,Zhongping Duan

Journal Article

A Resilience Approach for Diagnosing and Predicting HBV-Related Diseases based on Blood Tests

Gege Hou,Yunru Chen,Xiaojing Liu,Dong Zhang,Zhimin Geng,Shubin Si

Journal Article

Potential use of serum HBV RNA in antiviral therapy for chronic hepatitis B in the era of nucleos(t)ide

Fengmin Lu, Jie Wang, Xiangmei Chen, Dongping Xu, Ningshao Xia

Journal Article

Eliminating mother-to-child transmission of HBV: progress and challenges in China

Wenzhan Jing, Jue Liu, Min Liu

Journal Article

Review of recent guidelines for the management of severe sepsis and septic shock

Jin-Nong ZHANG MD, Bo PENG BA, Jamile WOODS MD, Wei PENG MD, PhD,

Journal Article

The imperative need to develop guidelines to manage human versus machine intelligence

Donald KENNEDY, Simon P. PHILBIN

Journal Article

Emergent limited perioperative transesophageal echocardiography: should new guidelines exist for limited

Yong G. Peng, Gregory M. Janelle

Journal Article

Guidelines for navigation-assisted spine surgery

Wei Tian, Bo Liu, Da He, Yajun Liu, Xiaoguang Han, Jingwei Zhao, Mingxing International Society for Computer Assisted Orthopaedic Surgery

Journal Article

Design guidelines for urea hydrolysers for ammonia demand of the SCR DENOX project in coal-fired power

Peng ZHENG, Xuan YAO, Wei ZHENG

Journal Article

dry-toilet collected matters from suburban areas of Ulaanbaatar, Mongolia, using biosolids quality guidelines

Xuan LIU,Zifu LI,Eric BOSC,Heinz-Peter MANG

Journal Article

Essential training steps to achieving competency in the basic intraoperative transesophageal echocardiography examination for Chinese anesthesiologists

Yong G. Peng,Haibo Song,E. Wang,Weipeng Wang,Jin Liu

Journal Article

Current advances in the elimination of hepatitis B in China by 2030

Shuye Zhang, Fusheng Wang, Zheng Zhang

Journal Article